Game that gets played the most: EverQuest, soon to be replaced by EverQuest 2. This is kinda weird because I've always stuck with FPS: UT, UT2K3/4, QII, QIII, Serious Sam, you name it. I guess Diablo I and II paved the way to actually having a progression, which got me looking into MMORPG's.
Now I primarily save my twitch games for lan-parties; still have to pick up Tribes: Vengence, and can't wait for Half-Life 2 (liked Doom3 also, I don't mind a single-player game if it's good). I have to reload FarCry as my HD died about 1/4 of the way through, and I haven't gotten around to replaying it. I don't know where I'm at in PainKiller, but I kinda got bored with it, but I'm sure I'll go back and play some more sometime (hence, I haven't deleted it off my hard drive).
Amazingly, I probably have about 5-6 games that are still in the wrapper: Max Payne 2, Wolverine's Revenge, Splinter Cell, Tron 2.0, Enter the Matrix (not in the wrapper but might as well be: sucked).