It's worth enabling and re-installing. Not only does it give you MANY more IRQ's (and hence less chance of conflicts) but also, the way it handles IRQ's is much muhc *MUCH* better, smoother, faster and more stable. Most people can literally tell the difference after enabling this option. Windows itself is much quicker and snappier.
It is a no brainer to enable this option, and feel fortunate that you even HAVE the option, as usually it only comes on dual CPU motherboards. I can't emphasize enough how incredible it is... I will never buy another motherboard that doesn't have it. Just remember, like was said... enable and then reinstall entire system. You will have to decide for yourself if it's worth it, but unless you just have to much precious stuff, go for it... the payoff is huge IMO.