RAID is the process of using multiple drives as one. There are several arrays.
RAID 0 - Combines two drives so that they are one, increases read/write speed of drives and gives you the capacity of both drives in one.
RAID 1 - is mirroring, two drives, one acts as the data storage drive, the other has the same exact info on it, but is only used as a backup (if u take the first one out or the first one is damaged, nothing will be lost)
RAID 5 - Three or more drives acting in a cycle of backing up and combining. (if you have 4 drives, two will become one and the other two are a mirror of the first two)
For most home users, a raid 0 array is best, it increases read/write performance as well as storage capacity. It is also the most practical seeing as how most of us do not have data of critical importance. I believe you can RAID any two drives regardless of brand, size or model but for best results it's good to use two or more of the same exact drive