The questions should be, "What do you want to do for a living?" Once you've answered that question you'll have a better idea which cert makes more sense. If you want to be a network engineer then you'll want to go with a Cisco cert. If you want to administer Microsoft solutions then go for an MCSE or MCP. If you want to be one of the cool elite Linux types, get an RHCE. If you want to spend the rest of your life supporting a legacy directory service that is dying a slow death, you'll want a Novell cert.
Ok, that past bit wasn't exactly fair, I don't like Novell. But if you google "migrate from windows to netware" you'll get 1 hit, whereas if you google "migrate from netware to windows" you get 390 hits, so I'm not the only one who doesn't like Novell. Since Windows 2000 and AD, many people have been moving to a Windows-based directory service. Mainly because it's already included and supported in the server OS, and there are a lot more people capable of administering Windows and AD than Netware. People just don't implement Netware very often these days, and those who have in the past are getting away from it. I would tend to stay away from them if you can help it.
Linux is getting bigger in the corporate space, and RedHat is leading the way. Being RedHat certified has decent payoff potential, though Linux adoption isn't anywhere near as prevalent as Windows.
As you may have guessed, Microsoft is usually a safe bet. They're not going anywhere, and they have interesting technology that is constantly growing. It's also fairly easy to learn, and there are plenty of places that offer classes if you want to go that route.
Cisco is also a solid bet. Nobody ever got fired for buying Cisco equipment, and they're looking like the leader for enterprise networking technology. They have a lot of great products available now, and they're really pushing this whole concept of "self defending networks" which is pretty interesting. Right now they're focusing a lot of effort on security, anti-virus/anti-spyware, intrusion detection, and so on via their partnerships with Trend Micro and other security companies. This is going to be a big growth area in the next couple of years. If you're interested in security (you indicated that you were working on your Security+) then this is a good option. Especially if it is coupled with another cert like an RHCE of MCSE, so that you will be familiar with security best practices from a systems and infrastructure point of view. Security is big business these days.
The certs that you currently have are a nice start, but they probably aren't going to be enough to get you a job any higher than helpdesk/pc tech at this point without a fair amount of experience to go with them. I don't say this to put you down, but as certs go the CompTIA stuff are regarded by employers as fairly low-level, "nice if you have them but not necessary" kinds of certs. They will help you distinguish yourself from other job candidates with similar experience, but they're not going to be the determining factor in whether you get the job in most cases.
Of course, the same could be said about most certs. Certs are nice to have, but your work experience is far more important. Most of us have worked with 'paper MCSEs' or other people who got certified via a bootcamp and were totally useless on the job. The cert can get you in the door but if you can't perform then you'll be right back out the door. Sometimes certs aren't even necessary. I've never gotten a cert, and with 6 years experience I'm an admin at my company (Microsoft and Cisco mostly) earning a VERY respectable salary. I guess what I'm saying is that what you know is a lot more important than what certs you have, so don't get distract by them too much.