Depends on your platform. Socket 775 processors could gain a little bit from the increased FSB speeds.
Today's 1366/1156/1155 processors don't explicitly gain anything other than an unstable QPI/QPI/Southbridge IF you are aware of using non-cpu-multipliers. Raising the bus speed on 1366/1156 will increase your RAM/Uncore speeds. If you then simply lower those multipliers to take it back to stock speeds, the only thing that has sped up is your QPI.
The QPI on desktop processors already has plenty of bandwidth. Unless you plan on sticking $3000+ worth of cards into your PCI-e slots, you won't be running out of bandwidth. AKA no gain.
1155 is a little bit different story, and without typing up a lot of stuff, don't touch it. Just use multipliers.