I'll also add, my wife wants to go there (Prague) soon. It seems to be a big tourist attraction, though I'm not entirely sure why outside of the architecture.
Well, it's similar to other European countries in many ways but has it's own unique points. People there just like to shoot the shit at the bar and discuss politics or football (soccer). The cuisine is generally German/Polish, pork, sausauge, chicken - just a lot of meat. In terms of stuff to do, it's just like any other major city - restaurants or museums if you're low key, night clubs if you're into that sort of thing, tourist tours, etc.
You're gonna need to keep your blinders on though, because the women there absolutely blow away spoiled, chubby american girls. Most of the young girls have that clubber vibe; they look great but they're a touch too into themselves. And the smoking is non-stop...I think they give out packs of cigarettes in elementary school.