California will suffer an 8.0+ earthquake, and the damage will make the cost to fix New Orleans look like pocket change.
Bush will play his surge game in Iraq, but the rapidly escalating violence will force his hand: Withdrawal will begin in 2007.
A major breakthrough in human cloning will occur - perhaps an actual cloned human will be announced - and Bush with his anti-cloning stance will become increasingly marginalized.
The lid will blow off the baseball steroid scandal, and it will be established that the vast majority of players are on the juice. Professional golf will begin to face its own steroid scandal.
Results from major new studies on climate change and evolution will force the anti-science crowd into full retreat in these areas.