As stated above, proper diet and exercise is all that it takes. The problem is, it takes a LONGER time, and being impatient, we all want results now. I understand that completely. But I'm going to say it again, proper diet and exercise is all it takes.
Now, with that said, lifting weights is your best friend. There are infinite routines out there. I prefer to lift higher weights for lower reps. Lifting raises your metabolism while lifting, and also for about an hour after lifting. Don?t lift for hours on end though. I lift for about 45 minutes to 1 hour, followed by a quick 3-4 mile run. If you want to get all technical, the lifting burns all the sugars/carbs in your body (which you are using for energy), and the immediate running will begin to burn the fat.
If you are insistent on taking supplements, then go with L-Glutamine and Carnitine. Both are essential amino acids. Read up on them first, and consult your doctor and all that good stuff. A good whey protein wont hurt either.
But seriously, all you need is diet and exercise. You can lose all the weight you want now, but there is no magic pill that?s going to keep you at that weight if you start eating garbage again.
Best of luck.