Some games need physX installed on your system to run.
If you deleted it after swithcing brands , just reinstall PhysX from gur3d. a later revision than included with ME2
I believe NFS SHift
Metro 2033
Borderlands ?
Its part of the game engine, runtime libraries ,dll calls that look for files installed from the physX package. Driver Sweeper , sweeps them. Or uninstalling physX.
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