Other than abortion most "single issues" I can think of are bunk.
There isn't a hell of a lot of difference in immigration policy between the parties and hasn't been for decades at least. Just a lot of fear-mongering by one of them.
Guns--wasn't Obama supposed to round up all the weapons? I guess eight years wasn't long enough to do it.
I'm far from a single-user voter but the environment/climate change is high on my list. The two parties are quite different on that one.
"Defund the police"--yeah, don't think most reasonable people want to have no police. Some whackos do. What most people want is for them to be fucking accountable, do their job, and stop lying when they do something wrong. Doesn't seem like too much to ask.
"low information" and "conspiracy thinking" go hand in hand to me. I had idiots telling me they "knew" hospitals were empty during covid, and that nobody was dying--it was all a scam. Meanwhile my brother works in an ICU and I knew several others working in hospitals, so I "knew" they were completely and totally full of shit. Where they got that garbage I don't know, but welcome to seemingly most of the American public. I don't even want to think of how many people believe total nonsense and vote accordingly--probably best to hope they don't vote at all.