I use V-syn on with my LCD,remember LCDs don`t refresh like CRTs but you normal set it to 60Hz.
Game settings should be run in native res (1280x1024)where possible to give the best possible image quality,you can use a lower res but the quality won`t be quite as good,also the game resolution really depends on your video card as well,since runnig at 1280x1024 for games will require a good video card like 9700 etc.