Yeah, you will have to run it at "2T Command Rate".
This is not a Mobo issue, I think that this is AMD CPU issue. Memory controller is inside the AMD CPU and it looks like for 4 DIMMs you have to use "2T Command Rate" setting, regardless of the motherboard you use.
Another thing, if your DIMMs are double-sided (chips are on the both sides of the DIMM module), then your Mobo would drop a memory clock speed from 200 to 166 MHz.
Do not warry about that either. Your VALUE RAM would only go to no more then 220 MHz, so if you overclock, you would have to drop memory to 166 MHz anyways. Let me explain a bit more... I also have an MSI K8NGM2-FID board, and I have a value RAM which would not go further then 215-220 MHz. So in the BIOS, I dropped memory clock from 200 MHz to 166 MHz, but I also increased the BUS SPEED from 200 to 250 MHz, that gives 25% overclok for my 2 GHz X2 3800. And (!!!) that also gives 25% overclock to 166 MHz memory as well!
So after my overclok I have CPU-Z showing my CPU running at 2.5 GHz and my memory running at 208 MHz (which is perfect for my value RAM, cause it would not go too much further than that)
So if you will be dropped to 166 MHz by your Mobo, do not warry, just give it 25% overclock and your memory would go to 208 MHz