From what I have heard is some motherboards have issues putting non video cards into the first PCIe slot on an SLI motherboard. Its not an issue with all of them as far as I know though. I do know that the SLI32 boards seem to suffer from this issue much more often. However in theory you should be able to. In practice, I would plan to only have 3 PCIe slots availible. This should give you roughly 24 SATA lanes, which I would hope is enough . I suggest checking the forums at storagereview.com, they tend to know much more about RAID Controllers and whatnot.