It depends on exactly what you mean.
If its digital cable, and you want it to be like your cable box is, then no.
The reason is that cable and satellite companies encrypt their feeds and I don't believe they allow the sale of tuners that can decode them (as they want to force you to use their stuff).
If you just want some of the main hi-def channels (basically ABC, NBC, CBS, PBS, and maybe FOX), then yeah. You'll need a clear QAM capable tuner (its unencrypted cable feed). If you have cable it absolutely has to feature QAM support, as ATSC is just for OTA.
Its possible that you might live close enough to a tower that you might be able to get those, its at least worth looking into.
Oh, and as far as I know, there aren't any cards that feature dual tuner support for that.
However, you might mean just the regular channels (even if you have digital cable, if you hook up a TV tuner, it will only decode the analog channels and none of the encrypted digital ones), which there are plenty tuners that can handle that.
Hope that helps.