Anti-virus software used to be a problem, but newer AV and fiewall programs and newer software, at least from competent makers, are much more aware of such conflicts. I suggest:
1. Always back up your system before installing any new software package.
2. Be VERY cautious before installing if you encounter such warnings with newer software. A good place to start would be to search Google for the software title "in quotes" and words like virus, spyware, etc. That should help you find out if there is any history of infections or attacks related to the software or if there are reported benign conflicts beween the software and any particular AV program.
Note -- Searching for the software title in quotes directs the search to the combination of words in the title.
3. Be even MORE cautious if the software installation requires you to be online when installing it. Being online with your AV turned off is like running around your town square buck naked with nothing but a "Kick Me" sign on your back.
Hope that helps.
