Are PBDEs harmful to human health?
The health effects of PBDEs have not been studied in humans. Instead, studies with laboratory animals provide information on the toxic effects of PBDEs. In these animal studies, PBDE exposure before and after birth caused problems with brain development. These studies observed problems with learning, memory and behavior. They also show that exposure to PBDEs during development can decrease thyroid hormone levels and affect reproduction.
These effects are observed mainly in studies with Penta forms of PBDEs. Some similar toxic effects are seen with Octa and Deca forms of PBDEs, but at higher levels than for Penta. There is some evidence from animal studies that Deca PBDE may cause cancer at high levels. Penta and Octa have not been tested in cancer studies with animals.
PBDEs have a similar chemical structure to PCBs (polychlorinated biphenyls), which have been studied in humans. (PCBs are no longer used in the U.S. For more information on PCBs go to
http://www.atsdr.cdc.gov/tfacts17.html). This suggests that PBDEs may be similar to PCBs in terms of toxic effects and their ability to build up in the environment and in people. PCBs are believed to cause skin conditions in adults and affect the nervous and immune systems of children. At high levels they may cause cancer. Studies are needed to determine if PBDEs have similar effects on human health.
http://www.doh.wa.gov/ehp/oeha...%20toxic%20are%20PBDEs