I go by what the vehicle MFG suggests. My last set of tires lasted a little over 50,000 miles which is what they were rated at. If you want to get really accurate PSI for your particular car, wait till the tires are completely cool. Then draw a chalk line perpendicular across the treads on each tire. Take note of where the chalk wears and adjust the PSI to keep the wear even across the entire tread. Takes a bit of work, and is a little bit of a PITA, but you *should* have accurate PSI settings for each tire.