Let's see. Say you have quite a few SATA SSDs lying around and are not yet comfortable with M.2's capacities or prices or reliability. You have 1 for OS drive, and 2 for RAID1 setup for data redundancy. That leaves you one more for your Steam folder and you are done.
Now, where do your VMs go? Virtual machines do not like sharing drives with other VMs, no matter what technology the drives are based on. What about emulation, maybe you are a developer and want to make sure your apps are compatible with as many Android versions. Want to have a discrete drive for your Android VMs? Fat chance. Or you just want to play around with your iDevices on Mac OS VM on your PC? Too bad go find a different board.
What about those "scratch disks" that I hear about from the graphics designers? Aren't those supposed to be separate volumes? Too bad you are not professional enough to use this board.
Or maybe you are encoding and transferring 4K footages via internal 10G network, and want to have a fast RAID0 volume. I am sure those are rather hot professions these days. Too bad this board is out of space. Get a RAID card for your RAID 0 array. Oh, and this board does not come with 10G ethernet (unlike other boards in the same price bracket) so you might as well get a 10G network card along with the RAID card. Oops, now you are almost running out of PCI-E slots, too!
And believe it or not DVDs and Blu-Rays are still around. You cannot download a movie of which quality matches the copy on Blu-Ray discs, and thumb drives are not durable enough to replace optical discs in certain, er, professional environments. This board may not accommodate such needs.
Not really a workstation board.