By 100k years either the rapture will have happened, or global warming and pollution will kill off everything. I imagine a large increase in respiratory issues, heat strokes, lot of droughts, lot of animals dying due to pollution and lack of water and food (less plants). We're always looking at expanding business and cutting down more forests, so as a result of that + continuous increase in pollution we will speed up global warming and it's related deaths. It will hit a point where it's actually very significant, but yet we will continue to pollute until we kill ourselves off.
Near the end when there's only a few million humans left things might stabilize so I don't think we'd actually be completely wiped out, but it could very well happen.