Brainonska511
Lifer
- Dec 10, 2005
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NMR operation and MRI development are used in all manner of departments - chemistry, biophysics/biochemistry, physics (or any number of other subdisciplines). I myself am in a chemistry program and department and we do biophysics research.Thanks for the extensive explanation and link. That has helped my improve my understanding a lot.
I got mixed up. I incorrectly thought that magnetic shielding was ONLY possible, with moving/changing magnetic fields. But of course magnetic patterns can be shielded, by guiding the magnetic flux through suitable materials.
Worse still. I would have expected it to be the Physics department. So I am feeling even more foolish, as it is the Chemistry department.
I was initially confused by the mention of 600 Megahertz. Because I thought it was low frequency, for the magnet. But I assume the extra coil(s), which allow high frequency modulation of the magnetic field, are what the 600 MHz are talking about. Presumably the 600 MHz is the "excitation" signal (Not sure of proper terminology, as I am NOT an MRI guru). Which makes the radio signals, become emitted from the sample(s), as they fall back to where the electrons were originally orbiting from.
So because the magnetic fields are reasonably shielded, the electronics (and cabling), are relatively straight forward. Except as you go inside the main part of the unit, which then has a huge magnetic field.
Before this thread, I thought/assumed that the huge magnet (of an MRI), was done by using HUGE permanent magnets, such as Neodymium Magnets.
I never realized it was done, by creating huge electro-magnets, and super-conductors.
The frequency listed is the Larmor frequency of the proton (1H) at that particular magnetic field. A lot of chemists will refer to a magnet size simply by the 1H Larmor frequency. It's the frequency at which protons will precess around the static magnetic field. But you don't have to apply a MHz field with your radio pulses. When you apply a radio field, this new field will create a smaller magnetic field, causing them to precess differently and coherently. You then record the radio signal as it relaxes back to its equilibrium, non-coherent state.
As for inside the magnet - there are still some metal things inside, like the probe, which is around your sample. If you've ever had an MRI done, the probe (the place where the RF signals are sent from and captured with) is the device they strap around your head or place on your chest. For an NMR, the probe is typically a long, cylindrical piece of metal with some wires and capacitors inside, so that the circuits can be tuned to the appropriate frequency. But for a lot of it, they use non-magnetic metals, so it isn't a problem putting it in and out of the magnet.
I don't think they can get very high fields with permanent magnets yet. But one of the bigger concerns, beyond a high field, is to have a very homogeneous field where your sample will sit. This is a lot harder to do with MRIs, because the bore is much larger than an NMR.
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