I can't say that I fix computers for a living but I have worked on several computers for pay. If possible, the best solution is to format the hard drive and do a clean install of the OS. That's the only way to be absolutely sure no malware remains in the system.
Now, I realize this isn't always feasible. In such case, what else can you do but use multiple tools to clean up the system, and perhaps use the computer for a longer test period after you think it's completely clean to give yourself greater assurance it's clean. I believe this testing phase should include numerous restarts of the computer and numerous web browsing sessions, assuming, of course, that you have anti-virus and firewall running during these test sessions to avoid new infestations.
After you do multiple scans with multiple cleanup tools, also use Task Manager to see what processes are running, and make sure there are none there that should not be there. This may require significant research time.
In addition to the tools mentioned in another post, I suggest using
CCleaner.
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