While it's impossible to predict with any accuracy, I'll play the game:
The most easiest to predict IMO is regarding health and genetics. I think all diseases will be curable. Aging can be stopped or reversed(which is kind of a terrifying idea if we're all still in one planet). You can select genetic traits like in Gattaca. Anyone can install cybernetic implants to enhance/aid basic functions such as ocular implants, call it Google eyeball(could let you record what you see, can see a broader light wavelength, etc), or a chip in the brain that allows you to perform daily things with just thought like shopping online or placing a phonecall.
On space frontier, it's much harder to predict what with the limitation of C. Things like terraforming and FTL travel in what we see in todays sci-fi still feels too unrealistic a possibility. My only guess is that energy is no longer an issue and easily produced efficiently.
Edit: oh and ATOT will still be around... in a museum... with an AI that will simulate daily postings and replies in real time for people to lol at.