I wasn't referring to a boot virus, just a regular virus in the OS on HDD, I just meant the boot drive containing the OS, not the MBR. This was in the past, I don't have one at all right now, I'm just wondering about the future now that I'll have 2 drives, because it seems I need to do this once or twice a year.
So basically, will a regular OS infection spread to your gaming installations HDD such that you cannot simply reinstall your OS drive but need to wipe the other one too?
i would - all it takes it a permuted dropper to be re-run (dll/exe/bat/graphic) to start it all over again. remember - what is NOT detected today - could never be detected if its not seen in the wild enough to warrant a virus signature. (hence why we have sites like virustotal
understand that a virus must be somehow "activated" to reinfect you. it is not enough to come in contact with it.
This means it would be, at most, infecting exe files (or dlls, etc). If you reinstall windows the system is not infected, even if you have an infected file on the drive, it will not magically infect the system unless you run it.
This is why I suggested the ESET scan. You don't have to delete it, its perfectly fine to have a file infected with a virus as long as you don't run it... and eventually that virus becomes obsolete (incompatible with current software, since viruses work on exploiting security vulnerabilities)
After you reinstall windows, all your (non cracked) games and programs will not be able to run... you will have to reinstall them. This process will replace any possibly infected files. This eliminates executables, which are the major vector for viral infections.
Movies, audio, pictures, and documents are highly unlikely to be infected / be able to actually infect your computer. And if they are, will require that you play / open them in a program with a security vulnerability...
So use quality open source players. eg: MPC-HC, Songbird, etc...
and make sure your MS office is up to date (or don't use MS office).
If you suspect a doc file, then you can open it in sandboxie:
http://www.sandboxie.com/
ESET's NOD32 antivirus is extremely capable and trustworthy and I would not worry if it found your documents to be clean. But once your system is infected it is pretty much done for, no antivirus program can "cure" an infected windows system... viruses download more viruses, hide themselves from anti virus programs, and sabotage windows system files that might allow you to remove them. Even if successfully removed you will end up with corrupted OS files and have to reinstall windows to fix those.
It is absolutely unnecessary for you to reformat your games/documents drive for a mere virus infection... But it is highly recommended you reinstall windows.