I are looking for a new RPG that has a science fiction theme like the Mass Effect series (including Andromeda).
Games we have played, so you can get an idea of what we like:
The Elder Scrolls series
Dragon Age series
The Outer Worlds definitely is a Sci-Fi RPG title. you played XCOM so modern Shadowrun games can be good. Borderlands series is a futuristic shooter looter which is also very popular.
another good TBS is Age of Wonders: Planetfall, its a 4X game with tactical turn based skirmishes.
BattleTech or Mechwarrior 5 also great titles more on the strategy side.