Strange CD Rom issues

[gf4200isdabest]

I'm having some issues whenever i try to play games. When I put the CD in the drive I can install things fine but when I go to play them it always says "insert the correct cd." I have this issue with all sorts of games and I have it regardless of whether i use my DVD drive, my CDRW drive, or my virtual cd drive. Anyone have any brilliant insight on how I could remedy my problem?