Yes, u can use mission in stealth moe, set up some mines. Or do what I did, throw a botaload of varous grenades at him, when he charges u, run out of the room, slide back in, shoot him till he charges again and keep doing it until he is dead.
I am at what I think is the absolute last battle (or real close to it) with Malek. I am waiting for my son to come home this weekend so he can be home to watch when we finish the game.
Good game, lots of fun!