BOINC is a client in itself. Previously, you could download both optimized BOINC clients as well as seperate optimized Science apps for the project - referring specifically to Einstein@Home.
A wonderful gentleman by handle of
akosf took to compiling optimized science apps to take advantage of the various instruction sets available in various processors; this was wholly seperate from the optimized BOINC clients that you could find on the Web, such as the Truxsoft ones as well as others. Because of the phenomenal improvements that
akosf was able to deliver to his science apps, many of us urged the E@H project admins to hire this guy, get him on their staff and delivering the science apps "officially", so that everyone downloading the client/app from the E@H site could benefit, not just those who happened to read the forums. The admins did exactly that, and now the client/app being downloaded from the E@H site is already optimized to take advantage of the various instructions sets of the processors out there.
As for optimized BOINC clients, that depends greatly on how each project is administered -- as some projects like E@H use a quorum system to grant credit, meaning that even if you happen to find an "optimized" client that reports higher numbers for "claimed credit", the project still issues "granted credit" based on what is submitted, typically, dropping the high number and low number of 3 units submitted and taking the middle number, which is very different than an average. For example, if you use an "optimized" client and submit a unit with a value of 80, and two others are put in at 10 & 15, the "granted credit will be 15, where as an average would be 35, but averaging isn't what's being done. The only way to really reap the "benefits" of an optimized client is to get as many people using them as possible.
There are some projects however that do NOT use a quorum type system, nor any other of comparing submitted results by one user against those of another, meaning that the "granted credit" is equal to the "claimed credit"! In a project using this scheme, an optimized client would be a HUGE advantage over those people not running such a client. My personal belief is that this is blatant cheating, but that's really a whole other subject.
Edit: I found a little write-up on the whole "optimized" thing in general in a message thread at the BoincSynergy's team site HERE