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spyware adware malware /trojans

Alright, so I got manipulated into helping a friend of my girlfriends track down the source of his computer's problems... Well, I started off by installing Avast which located over 700 viruses and deleting them. Then I ran both adaware and spybot. Of course, even after running all of these numerous times I still had a dialler attempting to connect to the internet! Sooo, I downloaded Panda Titanium, which I've been using for years... Well, it found a few more viruses and spyware components, but it periodically still finds "ISTBar" running here and there. Not yet willing to give in, I've scanned the PC with TrendMicro's free online scanner, which picked up 3 more trojans that were hiding out (Adserv, nvc32, adsuit). Spybot continues to pick up a "DSO Exploit" every time I run.
Anyone got any silver bullets? I'd actually like to shoot this Dell.
I would just wipe the system, but this is the guy's business computer (which is apparently also his sole source of porn (using my own mouse and keyboard, thanks)) and he needs the files on it. Of course, he's "not sure" where his install disks are either. Of course, if all is lost, I will take major heat from my girlfriend.
Anyone know of any other lesser known (but reliable) spyware removal tools?
Thanks!
Justin
 
Lavasoft Ad-Aware SE Personal is another one to try. Did you disable System Restore so the malware can't come back from the grave?

Also do a MBSA scan (link) and keep doing it until you have everything nailed down as far as the OS security. There's tips on getting those pesky weak/blank passwords fixed here under the ongoing prevention section. If you can get him to use a Limited account for his, uh, daily-driver uses, he will be a lot safer that way.

For antivirus protection, set it up with a free 15-day trial of Norton Antivirus 2005, which will recognize quite a bit of spyware, adware, Trojans and dialers. Make sure to max out all detection options. You might also want to take the hard drive right out of the Dell and use your own system to scan it with several companies' products.

Bigger picture: an OEM WinXP Home Edition CD and license is under $100, consider that if necessary.
 
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