this is a quote from an article I found:
If you read AMD's specifications for the Athlon 64 processor, you'll discover the admission that it can't handle the timing issues involved in running more than one double-sided module at the full DDR 400 speed. According to the same specifications, it states that systems with two or more double-sided modules can only be operated at the speed of DDR 333 modules.
As usual, AMD is being rather conservative with its specifications, probably in order to avoid as many problems as possible. Some Athlon 64 motherboards will run as much good-quality double-sided memory (i.e., made by Crucial) as the board can be fitted with without any problems, and others support a maximum capacity of particular brands of DDR 400 RAM that should run without problems.
here is the full thing:
http://www.pcbuyerbeware.co.uk/RAMProblems.htm#double
I don't know that I nessisarily agree with this. It may TECHNICALY run less stable, but I think in practice it's a negligable problem, deffinately not one I would let affect my purchase. I personally run DDR400 with my 64, and have NO stabillity problems (as far as 24 hours of prime95 is concerned) And I know a lot of people would say the same (even those with higher speed ram than 400)
It also sounds like a lot of this problem can be chipset related, so I guess choose your chipset carefully!
I guess in the end it's your call, I'd go dual sided because I like having a full gig (and if your thinking of 4x256 to keep it single sided, just remember, the more parts you have the more can go wrong, thus naturally increaseing instability) But maybe you're a little more picky than me.

At any rate, thanx for the ? This one made me think!