My Kodak DC3200 uses a serial port to transfer pictures. I'm about ready to sell it and get something better - I bought a CX6200 for my sister, and that thing uses USB - maybe 3 seconds per picture? The DC3200 takes a minute and a half each, and the pictures are ~75% the size of the CX6200's!
Other than that, I think I'm mostly legacy free. My trusty Acer keyboard, $6.95 at a computer show a few years ago, is still working fine, thanks to a complete internal cleaning - it's in the PS/2 port. Everything else is USB - mouse, scanner, Thrustmaster Tacticalboard, USB thumbdrive, and external hard drive.