I'm looking forward to KOTOR 2 and Republic commando, despite the fact that many recent Lucasarts games and movies have been big letdowns.
Also, Dungeon Siege 2, Battlefield 2, Black and White 2, Empire Earth 2, Age of Empires 3 and probably more if I reread PC Gamers from the past 2 years.
They do previews on tons of games that dont see daylight until 2-4 years later.
I'm still waiting on the Imperium Galactica 3 project which has changed names 4 times and changed owners 3 times. Elder Scrolls 4 is looking promising.
Serious Sam 2 has been out for a while now.
I look forward to all these games even when I know half will be big dissapointments and all of them have been delayed several times. I think its a holdover from my NES days. I'm just so deperate for entertainment.
PS. Duke Nukem Forver
EDIT: Since you asked about this years killer games, I think that if anyone of these isnt a huge dissappointment then it will be KILLER.