Here's a problem that is irritating...
Every so often the Smooth edges of screen fonts option (in Performance settings) spontaneously turns itself on. I'll go and uncheck it, click OK and it goes away, only to reappear later on (usually a day or two).
I'm running WinXP Pro, and I leave my machine on unless I have a compelling reason to restart or shutdown - and this problem has definitely survived several restarts.
Thanks.