I'm afraid so... there's stuff about it in the motherboards forum, it was mentioned in the news area a couple of days ago, there's a full explanation on xbitlabs. Apparently the SiS735 is rather poor at running the CPU and memory asynchronously (as it has to for 100/133), introducing wait states. The SiS745 currently has the same problem doing 133/166 which is what it has to do to support DDR333 memory...
I have two K7S5A boards, but I get to run them at 133/133, so no problems for me (-8