I haven't heard much really in terms of Compatibilty issues truthfully. I myself do not have a K7S5A (I've got an ECS K7VMA (KM133)), but you might ask some of the people who have bought this board, or the PCChips 735 board. I will say that I hear all these VIA horror stories, and I was worried, and I was trying to decide between K7SEM or K7VMA, and I took VMA because of the Savage4 video (Was looking for the best int. video for gaming), and I must say I've been impressed with my mobo/chipset and don't regret getting it instead of K7SEM. This was my first D-I-Y, and I haven't had a single VIA issue, with this chipset, so I haven't heard any major issues with 735, but if you're still parinoia, then ask those that do have it. Good luck.