For a network SetiQ no doubt about it.
For a single machine SetiDriver unless, the computer doesn't have a dedicated phoneline and you can't go to the location to manually dump the wu's very often. SetiQ allows you to specify a time for it to automatically dial in and do it's thing. I have it running on a remote system and it only connects at night while the user is asleep so it doesn't tie up the phoneline when they might need it.
SetiDriver is much easier to setup but I think SetiQ is the better program. My only complaint is there isn't an option to hide the setiQ dos box so you have to use a 3rd party hiding program such as trayer or hide it.
Edit: BTW setispy works just fine with setiQ.