Depends what you're putting on that screen but most Vid apps aren't configured for multi-zone setups. What I mean is, you can have your video card out put to multiple displays, any PC can do this as it can be used with multiple monitors. However if you put VLC on one screen to play 1 video, then in VLC's settings you tell it which video source you want to use as well as which audio source - if you choose one of the display port outs then that is what that app is configured for. So when you open that app, it will always play audio from the one display port you choose in settings. Now you could choose to install 3 separate installs of VLC, or whatever app you use as long as it supports multiple installs. Then you could just use one install for each screen. Then however your box will be running separate installs and multiple video/audio streams for each install. That could be insanely taxing on the system... Most - if not all consumer grade or inexpensive video playback applications will work like this.
The other option I see is putting a AVR that supports multiple zones in front of the TV