- Jan 7, 2002
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The mutant form of the bug multiplied more quickly, and was more lethal than its natural counterpart.
Researchers from the University of California at Berkeley, US, had actually been trying to disable genes and make the bacterium less deadly.
"This is one of the very few hyper-virulent organisms ever created," said scientist Dr Lisa Morici.
Tuberculosis is one of the world's biggest killers, and scientists are probing its genetic structure in a bid to find weaknesses that might be exploited by new treatments.
They disabled these genes, and expected to find a weakened form of TB as a result. Instead, the organism grew in virulence.
It killed laboratory mice within seven months of exposure, while those infected with normal TB survived the experiment.
Further investigations suggested that the genetic changes had the unexpected effect of undermining the body's own immune response against TB.
Professor Lee Riley, who led the study, said: "These findings came as a complete surprise to us.
"We thought we had made a mistake, so we repeated the test several times, and we always got the same result."
Text
Researchers from the University of California at Berkeley, US, had actually been trying to disable genes and make the bacterium less deadly.
"This is one of the very few hyper-virulent organisms ever created," said scientist Dr Lisa Morici.
Tuberculosis is one of the world's biggest killers, and scientists are probing its genetic structure in a bid to find weaknesses that might be exploited by new treatments.
They disabled these genes, and expected to find a weakened form of TB as a result. Instead, the organism grew in virulence.
It killed laboratory mice within seven months of exposure, while those infected with normal TB survived the experiment.
Further investigations suggested that the genetic changes had the unexpected effect of undermining the body's own immune response against TB.
Professor Lee Riley, who led the study, said: "These findings came as a complete surprise to us.
"We thought we had made a mistake, so we repeated the test several times, and we always got the same result."
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