Hey, Atom's dissin' my hood (well, just south of my hood)! Depends on what type of stuff you like to do... I personally hate the tourist stuff (it took me over a year to ride the cable car). Fisherman's Wharf is a tourist trap, just say no.
Touristy things: Palace of Fine Arts (probalby not what you're thinking... they filmed part of The Rock there, where Mason meets his daughter), North Beach (Washington Square), Lombard Street, GG Bridge, tea garden in the park, Asian Art Museum, Museum of Modern Art, the painted ladies at Alamo Square.
What type of food do you like and how much do you want to spend?
There's a million things to do, I could also recommend a bunch of clubs/bars if that's what your into.