It actually doesnt matter on the second dual channel pair.
And the 2 sets will run at the lowest determinator. So if 2 sticks are DDR3 1066 10-10-10 and the other DDR3 1600 9-9-9. it will all run 1066 10-10-10.
Make sure its all same voltage tho. And 1.5V is the standard. 1.6 or 1.65 aint.
It doesn't matter much; I'm running 16GB total with two sticks from Mushkin, one Corsair, and one Patriot. All are the same speed, same voltage, and roughly the same timings (which I tweaked manually so all the RAM timings match).
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