Most people will not even get close to the maximum "safe" thermal specifications. A lot of people complain about 40-50s temps as being too high, but the CPU's have no problems running at those temperatures. However, constant high temperatures from both your CPU and GPU can result in high case temperatures which can cause premature hard drive failures if you put a lot of stress on them. This is especially true for RAID arrays since the drive typically tend to run hot when in use.