yeah if the pci bus starts going above the 35 to 37mhz range hard drives can start to corrupt
i had a quantumn fireball hard drive (aventually went out on me) that would corrupt a few mhz lower than my other hard drives would, so it's different for each hard drive, vid card, and other devices.
but generally speaking overclocking the pci bus does nothing for performance and really reduces stability each 1mhz above spec it goes.
When overclocking of the agp bus performance is also negligable in most cases, and usually not worth doing unless the agp bus is already being saturated or "maxed" out (which really isn't happening enough right now with current vid cards to yeild noticeable performance increases)
people have been know to get a nice agp overclock approaching 80mhz to 100mhz, but again even those numbers don't really help performance.
PCI/AGP locks are great for us overclockers because we don't have to worry about stability issues and risks of corruption. And overclocks are no longer limited by the few extra mhz extra you can push the pci bus at the highest divider the chipset/motherboard supports.
it's a good thing
