The vehicle uses strut towers on all 4 corners yes? Is the rust anywhere near a strut tower mount point?
If so, then for long term structural integrity do not let it go or it will spread, at a minimum wire brush or sand away the rust and put a liberal amount of primer on it. Color coat that if deemed unattractive, or if the primer isn't rusty metal primer.
If removing all rust produces holes, fill those with fiberglass reinforced body filler, and a support mesh if needed, or even weld in new metal if it's that bad or the area flexes and later causes the body filler to come off.
Rust on an F150/etc body-on-frame vehicle's body panels or wheel wells is not necessarily the same problem in that most can rot away and not sacrifice the structural integrity much. The strut tower areas on unibody vehicles routinely flex. Metal flexes. Rust doesn't.
It would be easier to assess with pictures, others may be right that it is not significant if not near the strut towers.