Are you talking about blocking usb drives on computers connected to a domain?
This might help
https://support.microsoft.com/en-us...users-from-connecting-to-a-usb-storage-device
There is no easy GUI to do it unless you call Group Policy Editor an easy to use GUI.
There is another way to do it using GP:
http://techgenix.com/Control-USB-Devices-Group-Policy/