I don't think I'd use an HD Homerun with a wireless network. Wireless N might do it, but it depends. Let's say you have a show set to record on one computer. While that show's recording, you want to watch it on another computer. On your network, you now have HD Homerun --> recording PC --> watching PC. That wouldn't be a problem on a wired network, but it will likely saturate a wireless network if it's HD programming. This might be a moot point that would never affect you, but it's the reason I didn't go with an HD Homerun.
FWIW, I used to have a wireless G card in my gaming PC. When I would stream HD across the network, it was choppy. I ran a 50' Cat6 cable through my crawlspace and that fixed the jitters completely. OTA HD shows can be as much as 10GB/hour. In a perfect world, that should be able to stream across wireless G, but wireless is usually not a perfect world.
I've been using the HVR 2250 for 3-4 years with no problems whatsoever. On my other computers, I usually want to watch recorded shows. If I want to watch live TV, then I do have to go through the extra step of recording the show on my HTPC, but I've only had to do that about 5 times in the past 4 years, so it's a non-issue for me.