It will be used for many things, but the reasons I decided to go with 16GB are
(1) I will do some rendering and I might need more than 8GB
(2) RAM is cheap these days. When I made my current system 5 years ago I spend over $200 for 2GB. Recently I wanted to upgrade with another 2GB, but I was told that adding 2 more sticks of a different brand (I couldn't find the exact same RAM now) could compromise my overclocked system which was running stable for all these years. So for my new system I decided to better add more memory than I need and not to worry about upgrading it in the future.
Could adding 2x8GB instead of 2x4GB RAM result in lower overclock for an i7 2600k? I am aiming to something about 4.5GHz, so nothing too extreme.
One thing to keep in mind is that cost truly is a factor here. I haven't checked relative prices recently, but I'd guess that you're probably looking at $80-$100 for 4x4 gb and probably double that for 2x8 gb. If there is that much of a delta in price, I'd probably cheap out and grab the 4x4 kit. Keep in mind that if you have 4 sticks of ram in dual channel mode and one of the sticks goes out, your computer will still run in dual channel mode for the first 8 gb and will only drop to single channel if you needed more than 8gb for something. So if you lost one of the 4gb modules you'd probably still be ok at 12gb at least, and that saved money would put you that much closer to the next big upgrade, a better mobo/video card/cpu, etc.
edit: wow, I just checked out newegg. Here's the list of 4x4 and 2x8 kits sorted by price:
http://www.newegg.com/Product/Produc...4%20x%204GB%29
$75 for a decent set of gskill ddr3 1333, $80 if you want 1600
http://www.newegg.com/Product/Produc...2%20x%208GB%29
$100 for what looks like the same ram at ddr 1333, but price jumps to $150 for ddr 1600
From looking at that I'd definitely go with a 2x8 kit if you're ok with ddr 3 1333, and I'd probably get the 4x4 if you decide to go with ddr 3 1600.