I have done this for various different reasons in the past with wildly different combinations of drives. The outcome has always been different but universally I've found the following:
1) Peak performance in any aspect will never reach the same as when the drives are identical, its at best twice the slowest (raid 0) but often much below that.
2) The lowest performance indicator can be considerably below twice the slowest drive.
3) Random access can suffer badly, often so much that having a single drive would have been better.
I have never kept a system with different drives in it for very long, its always been a stop gap until I find an identical drive.
But what I would say is its quick to test with something like CrystalDisk giving a good indication of the drives individually and combined so you may as well see what happens in this case.