dainthomas
Lifer
I always thought it was kind of neat how the fuel isn't very dangerous or very radioactive until it is put in water (your moderator). Then, it essentially "wakes up" and takes a long time to put it back to sleep.
And yes, it can actually happen in nature, too:
http://en.wikipedia.org/wiki/Natural_nuclear_fission_reactor
I think to "wake up" they need to be in the presence of other fuel rods as well as a moderator. Bombarding each other with neutrons is what causes them to heat up and become radioactive.