Just about anything can make you appealing to a grad school. You want to try and differentiate yourself...but if you're going in for microbio, then grades are especially important (hard science and all).
Top on the list should be research/lab experience. Work as a TA, or after hours as a research assistant, lab tech, or whatever you can pull. Your school will usually have ways of setting this up for you.
Getting a job outside of class also helps, as does joining extra-curriculars. Rec sports show diversity, but don't forget an honorary society or two. Just make sure you actually participate, and take leadership positions if at all possible.
Basically, it's just like getting into college...only a LOT more competitive. Start studying a few months ahead of time for your GRE, pull your grades up, participate in something at your school, and you should be fine.
As someone mentioned up there: competitiveness varies GREATLY from program to program. Some are as easy as a community college, and some more selective than medical school. Do some looking around and find which colleges are best suited to your interests. Once you find a few colleges you like, do some further research. Look through articles published by faculty members and find professors that are studying topics you would be interested in. Grad schools always like knowing that you have an idea of what you're getting into.
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