I did for about a year in college. It made economic sense because my school sold a one-semester bus pass for $55. But it took 45 minutes to go a few miles, I had to transfer, and I still got dropped off over half a mile from my work.
I'd never pay full price to use the bus. It's actually quite expensive, $2.25 per ride during peak times. And for me to get to work, I'd have to transfer twice, and it would take over an hour (commuting by car takes ~20 minutes). Oh yeah, and my office is right next to a bus depot too.