I don't see why not. First of all, you need a program that will display the video-in. I don't know of any other than video editing programs, and I know you don't want to use those to play games, since usually you only have a small viewing area. The second thing, you need somewhere to plug in the sound. If your soundcard has the ports for the sound connectors (the red and white ones, always forget what they are called, I know my Hercules Game THeater XP does), then you can hear sound. So... I dunno. Im not talking from experience, its something I was actually going to try to do tonight, since my room mate is watching the Superbowl 😛